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Flagship 03 · Guideline Evidence Support

Clinical Practice Guideline
Development & Adaptation

Apply rigorous methodology to build the evidence base for context-specific recommendations, assess evidence certainty, and support transparent and interpretable recommendation development

通过严谨的方法学引导，系统构建支持特定情境推荐的证据基础，并评价证据可信性，支持透明、可解释的推荐形成

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Typical client challenges

Making every step from evidence to recommendation transparent

Many, differing recommendations

Existing guidelines may contain numerous or differing recommendations, making it difficult to identify unresolved clinical questions and areas requiring update

Priority questions need structuring

Priority clinical concerns need to be structured into clearly defined questions for systematic evidence retrieval and assessment

Dispersed evidence, mixed designs

Relevant evidence may be dispersed across different studies and study designs, making it difficult to establish a comprehensive, credible and traceable evidence base

Evidence-to-recommendation transparency

The link between evidence findings and recommendations requires transparent assessment of evidence certainty, key trade-offs and decision considerations

International guidelines need adaptation

International evidence or guidelines need to be adapted using local evidence and practice context

New evidence may warrant an update

Emerging evidence needs to be assessed to determine whether it may affect existing recommendations and warrant an update

How SRS Works

From recommendation mapping to evidence surveillance & update support

01Guideline recommendation mapping & evidence gap analysis
02Clinical question structuring
03Systematic evidence retrieval & synthesis
04Evidence certainty assessment & evidence profiles
05Evidence support for recommendation deliberation
06Evidence support for guideline adaptation & localization
07Evidence surveillance & update support
Typical Deliverables

Traceable evidence packages for recommendations and adaptation

Guideline recommendation map & evidence gap map

Structured clinical question framework

Evidence retrieval strategy & evidence review protocol

Systematic evidence synthesis report

Evidence profiles & Summary of Findings tables

Evidence certainty assessment

Evidence package for recommendation deliberation

Guideline adaptation & localization evidence package

Evidence surveillance & update brief

Selected Work

Representative cases

Quality Assurance

Rigorous methodology, transparent process, end-to-end traceability

Expert review at every node

Senior methodologists review question structuring, search strategies, evidence synthesis and certainty assessments. No step ships without sign-off

Traceable process

Search, screening, appraisal and recommendation rationale are fully documented; evidence profiles and SoF tables are auditable and reproducible

Methodological boundary transparency

We clearly state what the evidence can and cannot support, helping expert panels make trade-offs and judgments on an informed basis

Data governance & security

Complete processes for information security, publication compliance and conflict-of-interest management keep guideline programs well governed

Building a credible, traceable evidence base for your guideline?

Talk to our guideline methodology team. We usually respond within two business days

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